PROBIOTICS FOR HEALTHY INTESTINAL SUPPORT:

ProbioPureŽ boasts nine friendly human strains of bacteria to care for all areas of intestinal function and is suitable for daily use. Most brands of probiotic have only three strains. Equally important is that our probiotic contains human strains of bacteria rather than the inexpensive bovine strains!

This unmatched formulation includes specially selected strains of Lactobacillus acidophilus, L. rhamnosus, L. gasseri, Bifidobacterium longum strain B., B. longum strain M., B. bifidum., B. infantis, B. breve, and B. lactis. Listen to your gut feeling!

Supplementing with Probiopure Probiotic provides good company to the flora already there, and may help to calm the digestive system when antibiotics, travel, diet, pathogens, or any stress disrupt the normal flora causing various upsets.

Refrigeration of Probiopure Probiotic is not necessary, making it the most convenient probiotic on the market. Probiopure Probiotic is also heat stable and its potency is guaranteed for 3 years. Supporting well-being for all ages!

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Why Human Strains?

It is important to be aware that the human intestinal tract may be more sensitive to strains introduced to it than those introduced to the intestinal tracts of animals. What this means is that bacterial strains that are effective in one species of animal are not necessarily effective in another species. This is because the digestive tract varies from species to species and bacteria have to have certain characteristics in order to survive in the intestinal tract in which they are dwelling.

Specifically, bacterial strains indigenous to humans are more likely to survive in the intestinal tracts of humans than are non-human strains since they are specifically adapted to grow in the intestinal tracts of humans.1,2 They must be able to withstand stomach acid, in order to make it to the intestinal tract. They must be able to withstand intestinal fluids and they must be able to adhere to the lining of the intestinal tract to exert their greatest benefits.

Bacteria derived from dairy or other sources are less likely to remain in the intestinal tract of humans. They may afford only temporary, if any, benefits. On the other hand, human strains show better colonization and effectiveness. For this reason, each of our probiotic formulas is formulated with human strains.

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How Were the Human Strains Derived?

The bacteria strains used in Probiopure Probiotic were derived from single strains of bacteria donated by Microbiology Professors from the University of Tokyo and the Dokkyo Medical University of Japan. Each strain was obtained from a healthy, living subject in a one time collection. The bacteria of choice were, isolated, identified, purified and mass produced after this single collection.

Bacteria were obtained about three decades ago and have been naturally replicating in the laboratory every since for mass production. They undergo numerous tests to assure the bacteria are healthy and maintain their positive characteristics. Consuming bacteria is safer than eating produce from the grocery store, because consistent microscopic investigation would be impossible for produce but is commonplace where bacteria products are concerned.

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Why Take A Probiotic?

By providing large numbers of these friendly bacteria to the intestinal tract they may increase the population of these bacteria compared to other less desirable strains. These strains may then competitively inhibit the growth of undesirable strains and also inhibit the production of toxic substances produced by less desirable strains.3 Further, studies suggest that they may stimulate our immune system to suppress the growth of pathogenic or undesired bacteria.4-6

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Any Clinical Studies for Safety or Effectiveness of Probiopure Probiotic?

A clinical study of 180 patients from eight different medical facilities in Japan noted significant improvement in patients with soft stools or diarrhea from taking a probiotic product containing Wakunaga's Lactobacillus acidophilus (L. acidophilus) and Bifidobacterium bifidum (B. bifidum).7 Regarding constipation, a clinical study of 39 patients showed improvement in 95% of the subjects after taking a multistrain product including Wakunaga's L. acidophilus and B. bifidum.4 Another clinical study using the same product showed improvement in 58 of 64 subjects with constipation.7 Abdominal distension improved in 63 of 66 subjects and frequency, hardness and odor improved. Clinical studies conducted on nearly 300 subjects revealed no side effects in subjects taking Probiopure Probiotic.8,9

The probiotic strains used by Wakunaga (the manufacturer of our Probiopure Probiotic) have no toxicity based on basic toxicological and preclinical studies.

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References

1. Salminen, S. and Wright, A. V. (1993) ed. Lactic Acid Bacteria. Marcel Dekker Inc., New York, pp. 200-201.
2. Golden, B.R. and Gorbach, S.L. Ch. 13. Probiotics. The Scientific Basis (Fuller, R., ed.), Chapman & Hall, London, 1992, pp. 367-368.
3. Yamashita, M., Fujisaki, M., Ohkushi, E., Kaihatsu, K. and Uchida, S. (1987)Clinics and Microorganisms 13(b): 87.
4. Honma, N., Ohtani, K. and Kikuchi, H. (1987) On effects of lactic acid bacteria. Part II. Clinical effects. New Medicines and Clinics 36(1): 75.
5. Honma, N. (1986) On effects of lactic acid bacteria. Part I. Biological significance New Medicines and Clinics 35(12): 2687-2695.
6. Honma, N. (1974) Intestinal bacteria flora of infants and infection protection. Pediatric Clinics 27(11): 20.
7. In-House Clinical Study Conducted on 180 Patients from 8 Different Medical Facilities (Kobe University and associated hospitals.)
8. Willard, T. (1989) Occurrence of diarrhea with the use of Kyo-Dophilus. Chiron Consultants Inc. Calgary, Canada.
9. Willard, T. 1989. Kyo-Dophilus use in the reduction of Candida albicans symptoms. Chiron Consultants Inc. Calgary, Canada.

INGREDIENTS:

L. acidophilus KS-13, L.rhamnosus LCS742 & L. gasseri LAC343 , B. longum BB536 strain B. and B. longum MM-2 strain M., B. bifidum G9-1, B.infantis M-63 , B.breve M16V & B. lactis Bi-07

Each capsule contains 3 billion live cells! SUGGESTED USE: Take one capsule for adults (1/2 capsule for children under four) with a meal twice daily. For infants, sprinkle 1/2 capsule in food or juice.